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Specifically, intestinal bacteria can influence the endothelium of the vascular system via two primary mechanisms: firstly, the microbiota and its metabolites may activate the enteric nervous system, thereby affecting the brain centers that regulate cardiovascular function
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It is important to note, however, that with regard to the capability of the polycystins (and in particular of polycystin-2) to mediate a calcium influx into the ciliary cytosol, the initial controversial findings have been validated
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