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Further characterization of intra- and inter-tumoral heterogeneity via the TDLNs may eventually help with biomarker development and selection of combination therapies

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34 Fenton reaction and lipid peroxidation in hepatotoxicity According to a more recent review by Dixon and Stockwell, 35 there are “ three essential hallmarks that define ferroptosis: the loss of lipid peroxide repair capacity by the phospholipid hydroperoxidase GPx4, the availability of redox-active iron, and the oxidation of PUFA-containing phospholipids .” Although the term ferroptosis is new, the process of iron-dependent lipid peroxidation (LPO) as a mechanism of cell death in the liver has been recognized for 60 years