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Moreover, it was suggested that one of the reasons for such lacking of efficacy could be the activation of the Akt pathway due to S6 feedback loop driven by mTORC2 so, it has been proposed that a dual inhibition of mTORC1 and mTORC2 could prevent such Akt activation (211)

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Similarly, the loss of all 8 genes that function in the conserved oligomeric Golgi (COG) complex, that functions in intracellular transport, led to a uniform reduction in parasite development and an increase in actin pedestal formation during infection