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Mast cell degranulation Mycotoxins directly degranulate mast cells, releasing histamine that requires HNMT (a SAM-e dependent enzyme) for clearance
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Essential thrombocythemia is currently defined as a persistent thrombocythemic state (platelet count ≥ 450 × 10 9 /L) that is neither reactive nor associated with an otherwise defined myeloid malignancy (including polycythemia vera), primary myelofibrosis (including prefibrotic primary myelofibrosis), CML, and myelodysplastic syndromes
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