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Figure 1 from GHK – Copper Peptide in Skin Remodeling and Anti-Aging ! GHK- Cu in Skin Remodeling | Semantic Scholar
The mRNA and protein expression of the GSH biosynthesis pathway (GCLC, GCLM, GSS, and GSR) were downregulated in GCLC knockdown cells (Fig
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p53 directly inhibits the expression of SLC7A11, limiting the uptake of L-cysteine, thereby reducing the synthesis of GSH and reducing the activity of GPX4 (62).In addition, SAT1 and GLS2 are transcriptional targets of p53
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