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Everyone thinks GLP-1 drugs work simply because they make you eat less. That's definitely part of the story. But it may not be the entire story. Emerging animal research on tirzepatide suggests

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The theory described in the peptide literature is that a GHRH analog (signal one) and a ghrelin-receptor agonist (signal two) act in a complementary, even synergistic, way — producing a larger GH pulse together than either pathway alone, because the pituitary carries co-receptors for both inputs