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The researchers established two models: one is rat knee OA model induced by sodium monoiodoacetate and the other one OA chondrocyte model using IL-1β

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Preclinical research has also observed downregulation of pro-inflammatory cytokines including TNF-α, IL-6, and IL-1β, alongside modulation of NF-κB signalling pathways — positioning GHK-Cu as a subject of interest in inflammatory resolution research