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Finally, the statement of Marshall Urist, the BMPs concept founder, about the mechanism of the release from BMP delivery system to mesenchymal cell receptor mechanisms as obscure and under intensive investigation in academic and industrial laboratories (Urist, 1996) is true also nowadays, and it can be generally applied to any of the peptide + carrier complexes

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Reduced CCO activity impairs electron transfer in the mitochondrial respiratory chain, suppresses mitochondrial function and significantly lowers ATP levels