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The glycolysis regulator TEPP-46 can inhibit the pro-inflammatory effect of macrophages by obstructing the tetramerization of pyruvate kinase M2 (146) and simultaneously enhance the tolerance of macrophages to endotoxin (147)
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Increased flux through polyol pathway can decrease (Na + /K + ) ATPase activity and studies suggested that decreased activity of this enzyme may activate PKC pathway [19]
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