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However, preclinical data on animals (gerbils) showed that both U-101033E and U-104067F can significantly attenuate the post-ischemic loss of dopaminergic nigrostriatal neurons (Andrus et al., 1997)
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2.2 Hypoxia-mediated 2HG Various reaction conditions, including solvent, temperature, pH, oxygen concentration, and availability of substrate or cofactor, can profoundly influence enzyme function
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