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Parallel work used genetic approaches that involved conditional inactivation of the Raptor-encoding gene Rptor and found that a lack of mTORC1 caused substantial reductions in GC B cells that were especially marked for the NP-specific population and reduced both SHM and high-affinity IgG1 (to ~0.5× and ~0.05× normal levels, respectively) [79]
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doi: 10.1016/j.virusres.2006.01.020
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