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FIGURE 4 Conclusion and Perspectives Most of the METH-elicited neuropsychiatric consequences are attributable to its neurotoxicity, including direct damage to central dopaminergic and serotonergic terminals and the subsequent neurodegenerative changes upon the activation of neuronal autophagy, apoptosis, and necrosis (Davidson et al., 2001

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The definition was revised in the 2016 Covered Outpatient Drugs final rule (81 FR 5181 through 5183) and the 2020 Establishing Minimum Standards in Medicaid State Drug Utilization Review and Supporting Value-Based Purchasing for Drugs Covered in Medicaid, Revising Medicaid Drug Rebate and Third Party Liability Requirements final rule (85 FR 87022 through 87024)