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However, it has been noted that metformin dose dependently enhanced the platelet lactate production and reduced the complex I and IV activities, ΔΨM, and OCR, indicating that metformin-induced mitochondrial toxicity is dose dependent (Piel et al., 2015
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2016 · Treatment response Glutathione-S-transferases (GSTs) are associated with multidrug resistance of tumor cells and are involved in drug detoxification and control of apoptosis
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