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POLG-related disorders should be suspected in patients with a family history or suggestive symptoms of a POLG-related disorder, including but not limited to unexplained encephalopathy, refractory epilepsy (focal, myoclonic), status epilepticus at presentation, developmental delays, psychomotor regression, axonal sensorimotor neuropathy, myopathy cerebellar ataxia, opthalmoplegia, or complicated migraine with occipital aura
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It increases the expression of important DP signature genes, including Wnt, BMP, VCAN, BMP6, and Alx3 in SKPs, thereby creating a biomimetic niche for hair-inductive differentiation
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