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The antiretroviral drug zidovudine alters thymidine metabolism, likely by inhibiting dihydropyrimidine dehydrogenase (DPYD-1), which results in dTMP depletion and folic acid accumulation [75]
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Importantly, a recent phase I clinical trial in which CMF treatment was combined with a truncated NAC regimen revealed that addition of CMF modestly decreased the serum liver injury biomarkers keratin 18 and caspase-cleaved keratin 18 in overdose patients with no effect on serious adverse event reporting (Morrison et al
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