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Unlike fat-soluble vitamins that require fat for absorption and are stored in the liver, water-soluble vitamins like B12 are processed more quickly by the body and are not stored for long-term use

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Disrupting this pathway—either by severing kidney sensory nerves, selectively deleting the angiotensin II type 1a receptor (AT1a) in the subfornical organ (SFO), or using optogenetics to silence the kidney-SFO or SFO-paraventricular nucleus (PVN) connections—reduces sympathetic output, which in turn diminishes structural damage and functional impairment in the kidneys and heart in these models of CKD and heart failure (Cao et al., 2023)