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Iodothyronines can also be decarboxylated giving rise to a phenethylamine derivative called a thyronamine (TAM), such 3-iodothyronamine (T1AM) ( Thyroid hormones actions can be separated into two major groups: (1) the central effects that consist of a direct signaling on the central nervous system, and (2) the peripheral effects that correspond to direct effects in responsive tissues
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This inhibits transcription of Wnt/β-catenin signaling activity (Matsumoto et al., 2017
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