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There are three HO isoforms (HO-1, HO-2, HO-3) that have been described (Siow et al., 1999), although HO-3 may be a pseudogene derived from HO-2 transcripts (Hayashi et al., Figure 1 Cumulative evidence has shown that expression of HO-1 in the vasculature exerts protective effects against vascular inflammatory processes, thanks to its antioxidant, antiinflammatory, antiapoptotic, and possibly immunomodulatory properties
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