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APAP metabolism can be divided in three phases ( Figure 1 ): (1) The major bulk of APAP (85–90%) is metabolized by UDP-glucuronosyl transferases (UGT) and sulfotransferases (SULT), with conversion to glucuronidated (56–60%) and sulfated (28–30%) non-toxic metabolites, which are excreted through the urine ( (2) A minor fraction of APAP (2–5%) is directly excreted in the urine
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