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The mechanism of action may involve down-regulation of cyclin-dependent kinase activity, enhanced expression of p21, activation of caspase-3, inhibition of matrix metalloproteinase activity, and reduced expression of phosphorylated signal transducer and activator of transcription-3 (pSTAT3) [133]
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Studies in knock-in mouse models reveal that this mutation also amplifies glutamate synapse activity, contributing to excitotoxicity and neuronal damage (Kadgien et al., 2021)
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