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1H NMR (DMSO-d 6 ,400MHz)：12.88(br，1H)，7.78(s，1H)，7.41(m，1H)，6.91(m， 2H)，6.81(m，2H)，6.73(m，2H)，6.23(s，1H)，4.98(s，2H)，4.56(s， 2H)，3.68(s，3H)ppm.MS＝344(MH + )。 Example 1.4: synthesis of precursor 2- (4-methoxyphenoxy) -1- (3- ((thien-2-ylmethyl) amino) -1H-pyrazol-1-yl) ethanone

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