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However, it is important to note that the methods used were suboptimal, including use of 10g lactulose and 5g mannitol as sugar probes, urine collection from 0-5h (which, as noted in the methodology section, does not define the region of gut assessed), and the use of serum levels that do not necessarily reflect intestinal permeability

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Human trials: six randomised, double-blind, placebo-controlled trials reported no change in serum IGF-1 and no negative effect on carbohydrate metabolism (Stier, Vos and Kenley, J Endocrinol Metab, 2013)