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Now we know that the British National Formulary (BNF), that little booklet that is produced twice a year by the Royal Pharmaceutical Society and the Royal Society of Medicine which acts as a reference for doctors to consult in order to treat patients correctly, used to recommend a 1mg injection of Hydroxocobalamin every month when the injection was introduced at the start of the 1960’s

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It still appears as a line item on many payer forms, but the AASLD/IDSA HCV Guidance simplified treatment algorithm, introduced in 2019 and updated again in the panel’s 2023 guidance, allows genotype testing to be skipped for treatment-naive adults without cirrhosis, or with compensated cirrhosis, who are candidates for a pangenotypic regimen such as glecaprevir/pibrentasvir or sofosbuvir/velpatasvir