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However, high-dose oral therapy (1000–2000 micrograms daily) may be considered in specific circumstances, such as confirmed dietary deficiency in vegans without malabsorption, though this requires specialist assessment

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The peptide does not bind to growth hormone receptors in muscle tissue, does not stimulate protein synthesis or muscle hypertrophy, shows no effects on bone metabolism or growth, demonstrates no organ enlargement or proliferative effects, and avoids the connective tissue changes associated with growth hormone