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In addition, knockdown of NNT increased cellular and mitochondrial NADH/total NAD(H) in human SK-Hep1 cells under basal and ADP-stimulated conditions compared with control shRNA-transfected cells, whereas cellular and mitochondrial NADPH/total NADP(H) was much lower in NNT-silenced cells, which correlated with an increase in mitochondrial ROS generation (33)
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If MB was started as an adjunct to therapy (for instance, as an add-on in treatment-resistant depression or as part of a complex chronic fatigue protocol), the duration might depend on how the overall treatment plan evolves
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