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In PD models, expression of the retinoic acid-related orphan nuclear receptor Ξ± (RORΞ±) is significantly downregulated, accompanied by polarization of microglia toward the pro-inflammatory M1 phenotype, activation of disease-associated microglia (DAM), elevated pro-inflammatory cytokines (TNF-Ξ±, IL-1Ξ², IL-6), loss of dopaminergic neurons, and impaired motor function
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