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dQ/dt = rate of diffusion D= diffusion coefficient K= oil/water partition coefficient of drug A= surface area of the membrane across which drug transfer occurs h = thickness of the membrane through which diffusion occurs (C 1 − C 2 )= difference in drug concentrations in area 1 and 2 respectively Passive diffusion of peptides and proteins can be described by a combination of two processes: Paracellular transport: This process involves the transport of molecules via water filled pores/channels between cells
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Based on these observations, an ADC conjugated to duocarmycin through a cleavable enzymatic linker was designed against the B2M protein and used as a senolytic therapy
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