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Given that Aβ42 peptide oligomers are resident in the lipid bilayer (17, 18, 21, 120), coupled with the requirement that a lipid-resident free radical is necessary to initiate the processes of lipid peroxidation (free radicals outside the bilayer would be too reactive to survive entering the bilayer in the first place), consistent with the location of the Met35 residue of Aβ42, we posit that the sulfuranyl free radical of Aβ42 is the initiator of lipid peroxidation associated with this peptide (FIGURE 8)
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