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Aminophylline elevates intracellular cAMP levels via competitive inhibition of PDE3 and PDE4 , antagonizes adenosine A1 receptor ( ADORA1 ), regulates intracellular calcium signaling and synaptic vesicle cycling, upregulates the PPAR signaling pathway, and downregulates glutamatergic synaptic pathways simultaneously
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10.1007/s00232-005-0837-5
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