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An in vitro study examining the impact of AGEs on insulin signaling and glucose transport using a human ovarian granulosa cell line demonstrated that glycated albumin inhibits PI3K-specific AKT phosphorylation and prevents Glut-4 translocation to the cell membrane, indicating that intra-follicular accumulation of AGEs may interfere with physiological functions of granulosa cells contributing to impaired follicular development (Yuan et al., 2024)
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