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They demonstrated that ZHX2 knockdown increased ferroptosis in Huh7 cells by activating YTHDF2-induced degradation of GPX4 and SLC7A11, suggesting a potential targeted therapeutic pathway [154]
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Unfolding studies suggest that FgGST1 is a highly cooperative molecule because, during GdnHCl-induced denaturation, a simultaneous unfolding of the protein without stabilization of any partially folded intermediate is observed
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