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[239] with the same treatment suggested that soy isoflavones had weak estrogenic activity as pS2 expression increased in nipple aspirate of those patients with soy supplementation, but no effects were observed on breast epithelial cell proliferation, estrogen and progesterone receptor status, cell death, cell cycle progression, or Bcl-2 expression

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Every structural type of GS presents a composite active site where catalytic residues are contributed from two different protomers of the complex (Figure 1)