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BMS-777607 selectively inhibited the proliferation and colony formation of MET-overexpressing tumor cells, such as GTL-16, H1993, U87, PC-3, and DU145 cells, by suppressing MET autophosphorylation and the phosphorylation of downstream signaling molecules including ERK, AKT, p70S6K, and S6 306,390,391,392
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