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Erastin exploits the defective mitophagy-driven ROS accumulation to circumvent the ferroptosis resistance characteristic of EESCs, thereby enhancing its therapeutic efficacy
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Efficacy was also consistent regardless of whether data were analyzed using a conservative NRI analysis, in which participants who met prespecified treatment failure criteria or had missing data were considered to not have met efficacy outcomes, or using the observed analysis in which only participants with available data at the visit were evaluated
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