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According to the WHO classification, Group I (PAH) refers to idiopathic PAH, heritable associated with genetic alteration such as BMPR2 (most common mutations in PAH), ALK1, Endoglin, SMAD9, CAV1, KCNK3 (less common mutations), drug and toxin-induced (amphetamines, methamphetamines, cocaine, fenfluramine-phentermine), and PH-associated with other systemic diseases (connective tissue diseases, HIV infection, portal hypertension, congenital heart disease) (Simonneau et al., 2013)
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