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The application of over-expressing or knock-out and transgenic GPx1 mouse models overwhelming in vivo evidence for the protective role of GPx1 against oxidative injury and death induced by ROS and RNS
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In contrast, in the presence of a high dose of APAP (300 mg/kg), irreversible MPT pore opening and hepatocellular death were observed (Hu et al., 2016a)
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