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Loss of the mitochondrial electrochemical gradient impairs ATP production by the F 1 Fo ATP synthase and impairs neuronal energy metabolism [70,71,72]
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Orally administered melatonin is shown to alleviate formalin-induced nociception at a low dose, whereas high doses are reported to have anti-allodynia and anti-hyperalgesic effects in DM rats ( Melatonin alone or in combination with drugs such as gabapentin enhanced the hepatic gene expression of peroxisome proliferator–activated receptor and mitochondrial transcription factor-A
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