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Introduction Lung diseases, such as asthma, chronic obstructive pulmonary disease (COPD), pneumonia, lung cancer, COVID‐19, are a severe public health concern with a high morbidity and mortality, heavy healthcare and economic burden worldwide, and their therapy has urgent clinical need [1, 2]

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During breakthrough infection after vaccination, T-cell and plasmablast activation occur rapidly, while nAb and memory B-cell activation occurs ~2 weeks postinfection