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Additional IDA criteria included selection of ions above 400 m/z with intensities exceeding 10 6 counts, and dynamic exclusion of previously selected target ions for 30 s after 2 occurrences
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Notably, a similar phenomenon was observed in neurons from patients with MS, characterized by upregulated STING expression and markedly reduced STIM1 expression, suggesting that STIM1-STING-GPX4 axis-mediated ferroptosis is closely associated with neuronal injury in human MS pathology (Woo et al., 2024)
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