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Apart from catalyzing the conjugation of carcinogenic electrophiles to GSH, the α-class GSTs (GSTA1-1 and GSTA2-2) attenuate LPO by catalyzing the GSH-dependent reduction of phospholipid hydroperoxides and fatty acid hydroperoxides through its Se-independent glutathione-peroxidase activity, thereby terminating the auto-catalytic chain of LPO reactions resulting in decreased formation of 4HNE (Zhao et al., 1999
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