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Derived parameters, such as the TFR/log ferritin ratio, are evaluated to diagnose iron deficiency in inflammation, while the transferrin saturation (Tsat)/log hepcidin ratio is used to suspect iron-refractory, iron-deficiency anemia (IRIDA) [57] (Table 2)
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This adaptability suggests that combination strategies, involving either simultaneous or sequential targeting of multiple UPR nodes, may be necessary to preempt the evolution of resistant clones and achieve durable clinical responses
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