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KPV, the C-terminal tripeptide of α-MSH (Lys-Pro-Val), has been investigated for its interaction with NF-κB signaling, with researchers observing inhibition of NF-κB nuclear translocation and downstream inflammatory cytokine expression (TNF-α, IL-6, IL-8) in cell culture models

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This allows for continuous use without the risk of tolerance providing the same great effects each and every day