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As mentioned in Dahan and colleagues’ study [260], by employing in situ hybridization, MMP-1, MMP-2, and MT1-MMP mRNAs were detected in fibroblasts in the connective tissue adjacent to the SE, near inflammatory cells, which were negative for MMP transcripts
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Through molecular docking and in vitro ACCase activity assay, we found that the free acid of compound 83 could bind with acetyl-CoA carboxylase (ACCase) and displayed good inhibitory activity against E
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