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Specifically, in human HaCaT keratinocytes, MCF10A mammary cells, IMR-32 neuroblastoma cells, and U937 lymphoma cells, treatment with SFN or tBHQ, or knockdown of the Nrf2 repressor Keap1, has been reported to result in substantial induction of AKR1B10, AKR1C1, AKR1C2 , and AKR1C3 , which is as least as great as that observed for NQO1 [36, 39, 40, 136]
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