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Instead of a typical neutrophil and monocyte response, the resident immune system – mainly comprised of microglia – responds, followed by subsequent delayed recruitment of blood monocytes (Perry and Andersson, 1992)
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The cyclin-dependent kinase inhibitor p21 is induced by p53 in response to oxidative stress and competes with Keap1 for the binding to the DLG motif of Nrf2, thus compromising Nrf2 ubiquitylation and promoting the Nrf2-dependent antioxidant response (20, 34)
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