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This effect is suppressed by the administration of glibenclamide, a KATP channel blocker ( The surface of the gastric mucosa is covered by a layer formed of mucus, bicarbonate and phospholipids constituting the first line of defense of the gastric mucosa ( Prostaglandins, especially PGE2 and PGI2, are produced continuously via COX by the gastric epithelium and participate in the maintenance of stomach homeostasis and the healing of ulcers by acting by inhibiting gastric acid secretion and increasing mucus and bicarbonate production (Viana et al., 2016), 1,8-cineole ( Together, these data indicate that (-)-Carveol has gastroprotective activity related to cytoprotective properties, mainly involving a reinforcement of SHs in the gastric mucosa and increased mucus secretion and involves, at least partially, NO, KATP and prostaglandins

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