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From the genetics angle, there are some pediatric, congenital causes of 5-oxoprolinuria which not surprisingly involved defects in enzymes of the gamma-glutamyl cycle (in particular, mutations in glutathione synthetase and 5-oxoprolinase have been identified in these patients).

Peripheral Neuropathy

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EGCG is the principal polyphenol antioxidant present in green tea and has main potency in preclinical tests

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