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Exploring the Therapeutic Potential of Targeting GH and IGF-1 in the Management of Obesity: Insights from the Interplay between These Hormones and Metabolism
The most commonly used approach is in vitro or ex vivo tests using diffusion cells, or more recently, the parallel artificial membrane permeability assay (Skin-PAMPA) and phospholipid vesicle-based permeation assay (PVPA) (Figure 4) [40], allowing for the quantification of the permeation of CACs through the skin
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