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At the same time, a high-throughput screen for HRAS V12 -selective lethal small molecules in my lab in 2001–2003 revealed a new compound, which we termed erastin (for eradicator of RAS-transformed cells), that induced non-apoptotic cell death (Dolma et al., 2003) that depended on accumulation of oxidative stress and cellular iron levels (Yagoda et al., 2007)
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