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The D-2HG enantiomer is produced downstream of mutant isocitrate dehydrogenase enzymes in glioma and acute myelogenous leukemia, and the L-2HG enantiomer is produced under hypoxia
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These VLDL can also undergo lipolysis in the circulation, causing α-tocopherol to be distributed to circulating low-density lipoproteins (LDL) and HDL
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